Optimization of Glipizide Floating Matrix Tablet Using Simplex Lattice Design

The aim of the present study was to prepare floating matrix tablet glipizide by applying Simplex lattice design using kappa carrageenan, Hydroxypropylmethylcellulose K15M and sodium bicarbonate as independent variable. similarity factor (f2), time release 50 % drug 90 were taken dependent factors. A total 14 batches prepared given Design-Expert® Software (version- 9.0.6, Stat-Ease) response obtained for variables statistically evaluated. Radiological performed on healthy albino rabbits checking gastroretention optimized glipizide. results indicated that formulation G-simplex 8 with mg Hydroxypropylmethylcellulose, 30 carrageenan 10 alginate is highest desirability. in vivo X-ray imaging clearly revealed formulations remained afloat gastric fluid up 12 h stomach rabbit, which shows possibility remain human being desired period. It concluded simplex suitable efficiently optimizing